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KMID : 0358319960370111193
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Korean Journal of Urology
1996 Volume.37 No. 11 p.1193 ~ p.1200
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Histo-immunological Effect of Exogenous Testosterone on the Experimentally Induced Autoimmune Mouse Prostatitis
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홍성준
박동수/정병하/송윤섭/이동현
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Abstract
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the goal of this study was to examine the characteristics of the histo-immunological changes following induction of autoimmune prostatic inflammation achieved by subcutaneous allograft injection of the tissue homogentate of mouse ventral
prostate.
We
also investigated the effect of the administration of androgen upon the development of mouse autoimmune prostaitis.
Eight week old male C57BL/6 mice were selected and the presence, location and the degree of inflammation were identified after injection. The extent of infiltrations of the inflammatory cells in the prostate following the administration of the
exogenous
testosterone, the variation of the CD4/CD8 ratio of splenic lymphocyte and the variations of the interleukin-2 and tumor necrosis factor-alpha secreted by the splenic cells were also examined.
The autoimmune prostatitis of the mouse induced by subcutaneous allograft injection of the mouse ventral prostate showed histological findings similar to that of human. The degree of induction was in proportion to the amount of tissues injected
and
showed organ-specificity. Exogenous administration of testosterone resulted in partial inhibitory effect on the induction of inflammation which was thought to be related to the declease in the CD8+ T lymphocyte count and the functional inhibitory
effect
of the splenic T lymphocyte on the production of interlukin-2. Hovever, tumor necrosis factor-aalpha is presumed to be not closely related to the inhibitory effect of the administration of testosterone.
In the future, further studies on the variation of cytokine levels and the valued of sex hormones within the prostate and, moreover investigations in related to the humoral immune mechanism should be encouraged.
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KEYWORD
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